The Best, R&D Best pipeline for the transdermal delivery of drugs

Top Tier Transdermal Pharmacy
Pipe LineR&D strategy

Raphas’ DEN manufacturing technology has been quickly recognized in the derma cosmetics market, and its competitiveness has been increased by verifying its convenience and stability. Raphas is conducting further research with its partners in order to apply it to medical devices, specialized drugs, and vaccines.

Rapid commercialization strategy of improved new drugs applying microneedle technology

Bioequivalence can be verified by changing the formulation of an existing drug.
Based on the verification, a manufacturer can omit phases 2 and 3 of the clinical trials and mass produce a drug for rapid commercialization.

  1. High performance and high consumer convenience
    compared to existing licensed formations .
  2. Relatively low
    development cost
  3. Rapid commercialization
    with a high clinical trial
    success rate
Rapid commercialization with proven bioequivalence

R&D outcome

Raphas has completed 42 human application tests such as clinical efficacy tests and skin irritation tests to prove the safety and efficacy of all products.
Raphas has signed a partnership with a global vaccine manufacturer based on its DEN manufacturing technology, and is conducting joint R&D of candidate strains with the aim of developing new vaccines.

Drug substance

Raphas has signed a partnership with the global no.1 vaccine manufacturer
  • Signing of a joint R&D agreement (2017).
  • Signing of an agreement for the transfer of vaccine strains such as HPV, TdaP, HBV, and IPV materials (2018)
  • Signing of an MOU for the echnology transfer.
  • Engaged in joint R&D for animal testing of hepatitis B and polio vaccines.
Introduction of a new strain via technology introduction (license-in)
  • Development of a TB vaccine using a new drug candidate Mpg strain
  • In discussion for joint R&D with the global vaccine research institute PATH (RIGHT Fund)
Donepezil
  • Patch for the treatment of Alzheimer’s disease
  • Joint development
  • Engaged in joint R&D for animal testing of hepatitis B and polio vaccines
PTH
(parathyroid hormone)
  • Osteoporosis treatment patch
  • In-house development, L/O
  • Increased convenience and reduced pain compared to conventional injections
HDM allergen
  • Patch for the treatment of allergic asthma
  • Joint R&D
  • Signing of a joint R&D agreement with the global no.1 immunotherapy company (2019)
  • Engaged in a project with Severance Hospital, Korea’s best-known research hospital for allergic diseases

Medical device :
Drug absorption inducer

  • Brand : Therapass
  • Development background
    Coating drugs that are widely used in the treatment of skin diseases tend to have the disadvantage of having to administer too much of the drug or take it for too long as human skin's absorbance of the drug is low. To solve this problem, Raphas has developed a medical device designed to promote the absorption of coating drugs.
  • Partnership
    MIAT and Samoh Pharmaceutical
  • Development output
    1. Class 3 medical device licensed by the MFDS
    2. Completion of clinical study on drug absorption inducement for psoriasis patients
    3. Completion of clinical study on drug absorption inducement for prurigo nodularis patients

List of Academic Papers

Raphas has completed 42 human application tests such as clinical efficacy tests and skin irritation tests to prove the safety and efficacy of all its products.

  • 1. Study on the Improvement of Eye Wrinkles Using a Biodegradable Microneedle Patch, Korean Journal of Dermatology, 52, (9), 2014.

  • 2.  Development of dissoluble microneedles by using Droplet-born Air Blowing, Journal of the Japan Society for Precision Engineering, Vol. 82, No.12, 2016.

  • 3. Successful transdermal allergen delivery and allergen-specific immunotherapy using biodegradable microneedle patches, Biomaterials, 150, 2018.

  • 4. Ultrathin Metal Crystals: Growth on Supported Graphene Surfaces and Applications, Small, 181529, 2018.

  • 5. Comparative Study of Dissolving Hyaluronic Acid Microneedles with Trehalose and Poly(vinyl pyrrolidone) for Efficient Peptide Drug Delivery, Biomaterials Science, 2018.

  • 6. Enhanced Cancer Vaccination by In situ Nanomicelle-Generation Dissolving Microneedles, ACS nano, 12, 2018.

  • 7. The use of biodegradable microneedle patches to increase penetration of topical steroid for prurigo nodularis, European Journal of Dermatology, 28(1), 2018.

  • 8. Efficacy of bioactive peptides loaded on hyaluronic acid microneedle patches: A monocentric clinical study, Journal of Cosmetic Dermatology, 00, 2019.

  • 9. Enhanced anti-tumor immunotherapy by dissolving microneedle patch loaded ovalbumin, PloS One, 14(8), 2019.

List of Patents

  • Korea, Biodegradable solid microneedle and methods of preparing it, 0793615

  • Korea, Biodegradable drug needle and methods of preparing it, 0806026

  • Korea, Process of preparing solid microstructures, 0938631

  • Korea, Stent delivery device using a microcatheter, 1135154

  • Korea, Multi-functional hybrid microstructure and method of producing it, 1136739

  • Korea, Process for preparing solid microstructures by blowing and solid microstructures prepared by the same, 1136738

  • Korea, Biodegradable drug needle and methods of preparing it, 1254240

  • Korea, Stent delivery device consisting of stent wire conjugated with the microstructure, 1254245

  • Korea, Microneedle production apparatus, 1285085

  • Korea, Electro-microneedle assembly for cutaneous gene transfer in-situ and process for preparing the same, 1314091

  • USA, Process for preparing solid microstructures, 8,545,741

  • Korea, Process for preparing solid microstructures by blowing and solid microstructures prepared by the same, 1386442

  • Korea, Process for preparing biodegradable microneedle using hyaluronic acid, 10-1435888

  • Korea, Strain for green tea fermentation and method of preparing green tea fermentation liquid using the same, 1441097

  • Japan, Process for preparing solid microstructures, 5863824

  • Korea, Process for preparing solid microstructures, 1636069

  • Korea, Microneedle production apparatus, 1636070

  • China, Process for preparing solid microstructures, 201180067944.5

  • Europe, Electro-microneedle assembly for cutaneous gene transfer in-situ and process for preparing the same, 2737923

  • China, Electro-microneedle assembly for cutaneous gene transfer in-situ and process for preparing the same, 201280046973.8

  • Korea, Microneedle patch applicator, 1746048

  • Korea, Method of separating microstructure of microstructure patch, 1747963

  • Korea, Microneedle container, 1757866

  • Korea, Drug-releasing stand combined with biodegradable microstructure, 10-1760506

  • Korea, Supply device of viscosity material for manufacturing microneedle, 10-1784376

  • Korea, Process for preparing microstructures, 10-1784376

  • Japan, MANUFACTURING METHOD OF MICROSTRUCTURE, 6290988

  • Japan, MANUFACTURING DEVICE FOR MICRO-NEEDLE, 6290989

  • Korea, Microneedle patch for improving acne and process for preparing the same, 10-1873827

  • Korea, Micro-needle patch, manufacturing method thereof, and diagnosis method using the same, 10-1878414

  • Europe, MANUFACTURING DEVICE FOR MICRO-NEEDLE, 3189873

  • USA, MANUFACTURING METHOD OF MICROSTRUCTURE, 10,231,879

Pipe Line